A postdoc position for “DNP-enhanced solid-state NMR” will be available from September 2013 at
the Helmholtz center Jülich/ Heinrich Heine-Universität Düsseldorf.
One of the most demanding
challenges of biomolecular NMR spectroscopy is the inherently low sensitivity. Signal enhancement by
DNP is therefore a promising alternative to gain insights into systems which otherwise could not be
investigated. We will exploit the technique to obtain structural information on complex systems
(protein aggregates, and membrane proteins in lipid bilayers) which otherwise would be inaccessible
to structural investigations. Further, the possibilities of this technique for selective enhancement
will be exploited.
The candidate should hold a PhD in Physics or Chemistry or a related field.
Basic knowledge and experience in solid-state NMR or EPR spectroscopy as well as a strong interest
in physics and structural biology is a prerequisite. Experience with DNP is highly desirable. The
applicant should be highly motivated, open for new approaches and techniques, and able to tackle
demanding challenges. As most of the systems involve collaborations with other research groups, good
communication skills are required.
The biomolecular NMR center of the Heinrich-Heine University
of Düsseldorf at the Helmholtz Research Center Jülich (Forschungszentrum Jülich) offers an
exciting and stimulating research environment. State-of-the art solid-state NMR spectrometers
operating at 600 and 800 MHz are already available, a 600 MHz DNP spectrometer will be installed in
September of 2013, and the installation of an 800 with DNP is scheduled for 2014.
will be available for 2 years with the possibility of extension.
"Local Dynamics in Polyamides, studied by Solid-State NMR"
East Paris Institute of Chemistry and Job Description
Materials Science (UMR 7182 CNRS / University of East Paris - Créteil), Thiais, France
months postdoctoral position is opened in the framework of a collaboration between the CNRS/Rhodia
joint Research Lab "Laboratoire Polymères et Matériaux Avancés" (LPMA, UMR 5268), Lyon, France,
and the CNRS/University of East Paris - Créteil joint Research Lab "East Paris Institute of
Chemistry and Materials Science" (ICMPE, UMR 7182), Thiais, France. The postdoctoral researcher will
develop his/her research activities at ICMPE, Thiais, in the department "Complex Polymer Systems"
and will be co-supervised by Cédric Lorthioir (ICMPE) and Paul Sotta (LPMA). Rhodia is a global
specialty chemicals manufacturer with 5 multidisciplinary Research & Development Centers worldwide.
Lyon is the main Rhodia R&D Center for Europe. CNRS is the main governmental research organization
in France, involved in all scientific fields.
Partially polar polymers are very sensitive to
water. For example a dry semi-crystalline polymer like polyamide (PA) can absorb up to 12 wt% water
in saturated humid atmosphere (Relative Humidity = RH 100). The water content drastically affects
the glass transition temperature, which may be shifted from 80°C in the dry state down to -10°C in
the humid state, and therefore the mechanical and other properties.
The purpose of this work is to
combine advanced Solid-State NMR approaches to investigate the molecular dynamics in polyamides.
Selective Solid-State NMR experiments, performed as a function of temperature, will allow
identifying the specific types of motions corresponding to the various relaxation processes observed
in these materials, in the amorphous phase. The mobility and mobility gradients in the amorphous
phase located in the vicinity of the crystallites will be characterized by selective excitation of
the crystalline signal combined with 1H spin diffusion. Model polyamide materials with a variable,
controlled crystallinity will be considered. The dynamics will be studied both in the dry state and
in the presence of various amounts of water. These experiments will clarify the mechanisms by which
water plasticizes polyamide.
The position is to start any time. It is opened to an experimental
physicist/physico-chemist, with a PhD thesis in the field of polymer physics or chemical physics. An
experience in Solid-State NMR, if not mandatory, will be highly appreciated. Gross salary is about
2000 Euros/month. To apply, please send an application letter together with a detailed CV and
contact details of two academic referees to either of the following contact persons:
Laboratoire Polymères et Matériaux Avancés
85, rue des Frères Perret
Saint-Fons Cedex, France
Tel: +33 (0)4 72 89 64 66
Institut de Chimie et des Matériaux
Equipe ‘Systèmes Polymères Complexes‘
2-8, rue Henri Dunant
Tel: +33 (0)1 49 78 13 08
(1) Technical maintenance of the NMR equipment (e.g. cryoliquid refills), optimization, Job Description
implementation and updating of techniques and procedures; (2) Service management of the NMR
equipment; (3) Promotion of the PTNMR network activities; (4) Development and support of research
activities in the framework of the Natural Products and Materials Group’s.
A full-time position in the NMR department is open in Germany at the Max-Planck-Institut für
Kohlenforschung, in Mülheim an der Ruhr. We are looking for someone with a "Chemical Engineering"
or a similar university degree. The successful candidate will be principally involved with routine
and advanced NMR analysis in a broad range of chemistry applications for a world-class institute
pursuing fundamental research in all fields of catalysis. Some experience with solution NMR is
required. A basic knowledge of German and English is also expected.
A new postdoctoral position is becoming available at CEA Saclay (45 min by train from the center of
Paris) in high-field multidimensional NMR applied to large biological assemblies, to be coupled with
an exciting ANR granted project on the mechanisms of DNA gating in bacteriophages. The work is
focussed on the molecular bases of the head-to-tail connector assembly and function in bacteriophage
SPP1. It is based on functional and structural experiments, and in particular the coupling of
liquid-state and solid-state Nuclear Magnetic Resonance, X-ray crystallography, Electron Microscopy
and Molecular Modelling. Experience in advanced liquid-state and/or solid-state NMR is essential.
Expertise in protein purification and molecular modeling will be useful. Starting date is from
September 2011. A one year funding that can be extended to three years on a related project is
available. Please submit application and CV to: firstname.lastname@example.org.
Laboratoire de Biologie Structurale et Radiobiologie
iBiTec-S, CEA Saclay
Category:PDRA in Diffusion
A position for a Project Scientist is available in the Knowledge Centre for Materials Chemistry Job Description
(KCMC, http://www.materialschemistry.org) at the University of Manchester. The role is focused on
the development and delivery of a capability to use diffusion NMR to investigate the dynamic
behaviour of colloids and nanomaterials in aqueous dispersions. This work would be done in
collaboration with external sponsors including industry, charities and research
Candidates should hold a PhD in chemistry or materials science, and a strong research
track record in NMR spectroscopy and specifically in diffusion NMR, the related data analysis, and
the use of these techniques to investigate the association and behaviour of molecular assemblies in
liquid media. Experience in colloid and surface science is also required. Experience of working with
industry is desirable
The successful candidate will be working as part of a large research team
and will be expected to communicate results at project meetings, in written reports and to
industrial sponsors. Short-term projects will be based on a number of clearly defined goals that
must be delivered in a timely manner. We therefore seek highly motivated candidates with excellent
communication and interpersonal skills, with the ability to interact with persons at all levels
within the academic and business communities, and who would enjoy working in a challenging
environment and interacting with industry. The position will be particularly suited to candidates
who are interested in both fundamental AND applied aspects of science.
The closing date is 18th
April 2011; further details may be found at
http://www.manchester.ac.uk/aboutus/jobs/vacancies/research/vacancy/?ref=113848. For informal
enquiries please contact Professor N Tirelli (email@example.com).
A position is available at the Université de Lyon (France). The
selected candidate will join Job Description
Isabelle KRIMM's team as a post-doc for
two years and will work on a project funded by the
National Agency for
Research (ANR). The general framework of the project is the study of
protein-ligand interactions and fragment-based drug design by NMR. The
candidate will be
involved in NMR experiments and/or modelisation
A post-doc position (Szyperski laboratory at SUNY-Buffalo) is available in the area of
Research focuses on development of new NMR methodology and applications to
study protein structure and folding.
The successful candidate should have a strong background in
Bio-NMR spectroscopy. Basic skills in routine molecular biology / protein biochemistry are
We collaborate intensively with our colleagues in the Northeast Structural Genomics
A CV and three letters of recommendation are required (please
email to firstname.lastname@example.org).
Salary will commensurate with experience.
A post-doc position (Szyperski laboratory at SUNY-Buffalo) is available in the area of
Research focuses on the early detection of epithelial Ovarian Cancer and the
of the associated malignant metabolic phenotype.
The successful candidate will
collaborate with SUNY-Buffalo biostatisticians,
Roswell Park Cancer Institute clinicians, and mass
spectrometry (MS) experts.
Firm knowledge in NMR / metabolic research and interest in MS is
A CV and three letters of recommendation are required.
Salary will commensurate with
A post-doctoral position is available in the field of dynamics of molecular clusters and collective Job Description
dynamics in liquids in homogenous and heterogeneous environments. Major goal is experimental
characterization of structure, rotational and translational dynamics, formation, decomposition and
reorganization of molecular clusters. A key method is NMR spectroscopy, especially measurements of
nuclear spin relaxation and measurements of molecular self-diffusion by means of pulsed field
A postdoctoral position in centriolar structural biology is available in Oxford Biochemistry.
Candidates with NMR and/or crystallographic background are encouraged to apply. For more information
and application instructions please follow the Naturejobs link.
A postdoctoral position is available immediately for an NIH-funded project on CEST NMR/MRI Job Description
methodology development at NYU.
A postdoctoral position is available in solution NMR of proteins or metabolomics at OSU Job Description
An openings for a postdoctoral associates to work on structural and functional characterization of
proteins involved in vesicle trafficking or cell surface carbohydrate interactions is available in
the Prestegard laboratory at the University of Georgia. These are challenging projects involving
both protein-protein and protein-membrane associations. The work is well illustrated by our recent
publication in /Nature Structural and Molecular Biology /(17(7):876-81, 2010). The lab has access
to excellent NMR instrumentation, including 800 and 900 MHz instruments with cryogenic probes. We
also have strong biochemical collaborations that facilitate preparation and characterization of
samples. Athens is a University town in the Southeastern part of the United States with excellent
cultural amenities and a moderate cost of living. Those interested should send a letter describing
their experience, along with a CV and the names of three individuals we might contact for reference
letters. The University of Georgia is an AA/EEO employer.
Currently we are looking for a post-doctoral researcher in the area of para-hydrogen induced Job Description
hyperpolarisation (PHIP). The position aims specifically for development of the PHIP methodology and
instrumentation for screening, biomarker research and/or molecular diagnostics.
(initially 2 yrs; extension is possible) should have a background in (Physical) Chemistry and/or
Analytical Sciences with knowledge of MR spectroscopy (e.g. NMR or MRI) and an interest in
methodological development and instrumentation. Expertise in para-hydrogen based NMR technology is
We have an opening for a postdoctoral fellowship in MAS-DNP NMR at the Institute
for Nanosciences and Cryogenics (CEA - Commissariat à l'Energie Atomique et aux Energies
Alternatives) / University of Grenoble).
Starting date: before the end of 2012.
The lab is
equipped with a state of the art Bruker MAS-DNP system (400 MHz / 263 GHz) and is currently running
a program to access MAS temperatures < 100 K. The lab also hosts a second 400 MHz system equipped
with 1.3 / 2.5 / 3.2 / 4 mm probes and can access high field instruments through the French TGIR
framework (http://www.tgir-rmn.org/). Access to 9 GHz EPR is possible in the lab and access to high
field EPR instruments is also possible on campus (collaboration with LNCMI/CNRS,
Researchers with a strong background or interest in Dynamic Nuclear Polarization / NMR
methodology and its application to bio-molecules/materials are particularly welcome to
This fellowship is funded by the French National Research Agency (ANR). The initial
duration is 12 months with an additional 12 months extension upon results.
information regarding details of the research and of the appointment, interested candidates should
contact me directly at email@example.com.
Gaël De Paëpe
Experimental Officer working in solution-state NMR service. PhD level post - non fixed term. Job Description
The successful candidate will assure the technical support of the three
liquid-states NMR spectrometers of the Department of Organic Chemistry. He will operate a 500 MHz
Bruker spectrometer equipped with a helium-cooled probe and supervise the "open access" to the two
additional spectrometers (300 and 400 MHz spectrometers). He will also train the users for the
"open access" and optimise the sample changer operations.
In principle this is
technical position, but the involvement of the candidate in research projects will depend on the
competence and ability of the candidate to pursue projects in parallel to his main duties. We expect
the candidate to realise experiments such as dynamic studies, diffusion measurements, kinetic
measurements and other special but simple experiments requested by the members of the
The candidate should have good technical abilities and excellent
competences in computer programming and automation techniques. A chemistry degree is a plus but
other scientific backgrounds will be considered. The basic position is a "Classe 16" (86'000
CHF/year) but it may depend on the background and previous experience of the selected candidate. The
temporary position (starting November 2013) may evolve into a permanent
Geneva is a very international and pleasant city to live in. The
scientific level of the Department is excellent and attracts top researchers. It is composed of more
than 50 PhD students and postdocs. A group active in NMR methodology development and applications to
chemistry and biology should contribute to this outstanding environment.
knowledge of English and notions of French (or a strong motivation to learn it) are required.
NMRTEC is opening a position for a doctoral thesis in the field of analytical chemistry dedicated to
complex system and combinatorial chemistry.
In a part of the ITN READ European network, it is
intended to conduct an extensive study on the development of analytical methods for the analysis of
complex mixtures. This will include the study of large chemical libraries, auto-assembling systems,
complex protein ligand interactions, and the study of polymers and disordered biological systems.
Methods developed will include mostly NMR (1D, 2D, and multinuclear), diffusion measurement by NMR
(DOSY) but also other techniques such as SAXS and mass spectrometry.
This is a joined PhD project
between NMRTEC and the biomolecular NMR academic laboratory (IGBMC, Dr. Marc André Delsuc).
successful candidate should have strong interest specifically in NMR but also in analytical and
spectroscopic techniques. A good knowledge in biological and pharmaceutical sciences is an
According to EU rules for ITN projects the applicant:
- has less than 4 years of
experience since gaining a university degree and has not been awarded a doctoral degree;
not be a national of the State in which the hosting partner's research team is located (France);
must have resided in the France for no more than 12 months during the past 3 years.